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Acetazolamide has been recommended for channelopathies such as hypo and hyperkalemic periodic paralysis, but what is the MOA? |
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It works in hypo kalemic paralysis because of it induces metabolic acidosis and thus potassium conservation. Hi, thanks for your answer. That makes sense in treating hypokalemic periodic paralysis because of the H/K+ antiport system, however I read that carbonic anhydrase inhibitors can also be given in hyperkalemic PP which does not make sense to me, because the acidosis would cause K+ to be pumped out of the cells and worsen the hyperkalemia.
(Aug 17 '10 at 16:28)
NeuroGirl
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