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9 Questions

Best way to differentiate a satellite potential and a nascent MUAP on EMG
Both signify a neurogenic process (early reinnervation). What is the best way to differentiate the two on EMG? Also, I read that a satellite potential is "time locked" which does not make sense to me since these are unstable potentials ...
Why do you NOT see an increase in duration with a conduction block?
My understanding is that there is a decrease in amplitude AND area in conduction block, but why is there not supposed to be an increase in duration as well?
What is the mechanism of action of acetazolamide in channelopathies?
Acetazolamide has been recommended for channelopathies such as hypo and hyperkalemic periodic paralysis, but what is the MOA?
What is more sensitive in detecting axonal loss--fibrillation potentials or decreased recruitement--and why?
I have read that both are seen very early in axonal loss, but there have been conflicting statements as to which one is a more sensitive indicator for axonal loss.
Why do oral steroids worsen optic neuritis?
We know that IV steroids hasten recovery, but why would oral steroids actually worsen the natural course?
Why do you treat adrenoleukodystrophy with Lorenzo's oil?
Adrenoleukodystrophy is caused by defective oxidation of VLCFAs and the treatment is to give fatty acids (lorenzo's oil) -- why wouldn't giving this exacerbate the disease? I would think the patient would not be able to break down those fatty ...
Why are cholinesterase inhibitors not effective in patients with Musk positive Myasthenia Gravis?
I also read that cholinesterase inhibitors may actually worsen symptoms in Musk positive patients??
Why does giving a calcium channel blocker work in familial hemiplegic migraine but giving a sodium channel blocker for Dravet's syndrome contraindicated?
My understanding is that familial hemiplegic migraine involves the mutation of the P/Q type calcium channel, so giving a calcium channel blocker such as diltiazem has been proposed to work. But Dravet's syndrome involves the mutation of the Na channel, ...
Why are certain muscle groups affected in Inclusion body myositis?
Why is there a predilection for certain muscle groups (ie finger flexors, quadriceps) in IBM? I would think there would be no difference in the muscle fibers in these muscle groups.
4 Answers
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12 Tags
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emg_and_ncs
× 4 channelopathies × 3 optic-neuritis × 1 leukodystrophies × 1 parkinsonism × 1 clinically × 1 isolated × 1 syndrome × 1 ivig × 1 iga × 1 |
myasthenia-gravis
× 1 myopathy × 1 |
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